Journal
TALANTA
Volume 78, Issue 3, Pages 1051-1055Publisher
ELSEVIER
DOI: 10.1016/j.talanta.2009.01.001
Keywords
Spectrofluorimetry; Levodopa; Propranolol; Feed-forward neural network; Urine
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The simultaneous determination of levodopa (LD) and propranolol (PRO) using fluorescence spectrometric technique is described. The method involves measuring the natural fluorescence of these drugs in the micellar media of sodium dodecyl sulfate (SDS) using principal component analysis-feed-forward neural networks (PC-FFNNs). Experimental conditions such as effect of pH and SDS concentration were optimized. Under the optimum conditions, the linear determination ranges of LD and PRO are 2.0 x 10(-8) to 1.0 x 10(-5) mol L-1 and 3.6 x 10(-9) to 1.8 x 10(-6) mol L-1, respectively. A set of synthetic binary mixtures of LD and PRO was prepared and their concentrations were predicted by the proposed method. Satisfactory results were obtained by the combination of fluorescence technique with chemometrics methods The. method was successfully applied to the determination of LD and PRO in tap water and In urine samples. (c) 2009 Elsevier B.V. All rights reserved.
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