Journal
TALANTA
Volume 78, Issue 2, Pages 418-423Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.talanta.2008.11.042
Keywords
Molecularly imprinted polymer; Isoxicam; Spectrophotometry; Pharmaceutical and biological samples
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Funding
- Isfahan University of Technology Council
- Center of Excellency in Sensors
- Green Chemistry Research
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A selective molecularly imprinted polymer (MIP) has been synthesized for isoxicam pre-concentration, followed by its spectrophotometric determination based on hydrogen bonding interactions between examined drug and alizarin yellow GG. This method is able to evaluate isoxicam in range of 1.0 x 10(-3) to 20.0 mu g mL(-1), with a limit of determination of 1.0 ng mL(-1). The retention capacity and pre-concentration factor of prepared sorbent are 18.5 mg g(-1) and 200, respectively; and the prepared MIPs can be reused at least for five times. The MIP capability for isoxicam selection and extraction from the solution is higher than non-imprinted polymer(NIP). Under optimum conditions, this procedure can be successfully applied to assay trace amounts of isoxicam in pharmaceutical and biological samples. (c) 2008 Elsevier B.V. All rights reserved.
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