Journal
TALANTA
Volume 79, Issue 2, Pages 129-133Publisher
ELSEVIER
DOI: 10.1016/j.talanta.2009.02.022
Keywords
Antibiotics; DNA; Interactive mode
Categories
Funding
- Natural Science Foundation of China [20335030, 20775060]
- MOE P.R.C.
- Polymer and Material Science of Gansu Province
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This paper focuses on investigating the structure parameters of antibiotics which have decisive influence on the interactive mode between antibiotics and DNAs. The analytical results of Best Prediction Set Support Vector Machine Method (BPSSVM) show that the number of N atoms, the number of double bonds, the number of lone-pair electrons, the molar refractivity and the molecular radius are the main structure parameters which functionally decide their reactive modes. It is clear that the BPSSVM is potent in predicting the interactive modes between antibiotics and DNAs. (C) 2009 Elsevier B.V. All rights reserved.
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