Journal
TALANTA
Volume 74, Issue 4, Pages 512-517Publisher
ELSEVIER
DOI: 10.1016/j.talanta.2007.06.012
Keywords
tryptamine; phenethylamine; GC/MS; ESYMS; MALDI/TOFMS
Categories
Ask authors/readers for more resources
Certain characteristic fragmentations of tryptamines (indoleethylamine) and phenethylamines are described. Based on the GC-EI/MS, LC-ESI/MS and MALDI/TOFMS, the mass fragmentations of 13 standard compounds, including (x-methyltryptamine (AMT), N,N-dimethyltryptamine (DMT), 5-methoxy-alpha-methyltryptamine (5-MeO-AMT), N,N-diethyltryptamine (DET), N,N-dipropyltryptamine (DPT), N,N-dibutyltryptamine (DBT), N,N-diisopropyltryptamine (DIPT), 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT), 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT), methamphetamine (MAMP), 3,4-methylenedioxyamphetamine (3,4-MDA), 3,4-methylenedioxymethamphetamine (3,4-MDMA) and 2-methylamino-1-(3,4-methylenedioxyphenyl)butane (MBDB), were compared. As a result, the parent ions of these analytes were hard to be obtained by GC/MS whereas the protonated molecular ions can be observed clearly by means of ESI/MS and MALDI/TOFMS. Furthermore, two major characteristic fragmentations, namely and alpha-cleavage ([M + H](+) --> [3-vinylindole](+)) and beta-cleavage ([M + H](+) --> [CH2N+RN1RN2]), are produced when the ESI and MALDI modes are used, respectively. In the case of ESI/MS, the fragment obtained from (x-cleavage is the major process. In contrast to this, in the case of MALDI/TOFMS, the major fragment is produced via beta-cleavage. The ionization efficiency and fragments formed from either alpha- or beta-cleavages are closely related to the degree of alkylation of the side chain nitrogen in both cases. (C) 2007 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available