Journal
SYNTHETIC COMMUNICATIONS
Volume 44, Issue 11, Pages 1521-1578Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/00397911.2013.828757
Keywords
1H-pyrazole; Anticancer activity; N-substituted pyrazole; pyrazole; pyrazolopyrazole; synthesis
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Pyrazole is a versatile lead compound to design potent bioactive molecules for drug discovery and development, particularly in cancer therapy. The aim of this review is to present the most recent deeds in the field of synthetic route made for functionalized pyrazole derivatives active against cell proliferation disease. The review article covers the synthesis of 1H-pyrazole, synthesis of N-substituted pyrazoles, synthesis of pyrazolopyrazoles, and synthesis of pyrazoles fused with a naturally occurring moiety. Some of these reported compounds have passed the preclinical or initial-phase clinical trials for their anticancer activity.
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