Journal
SYNTHETIC COMMUNICATIONS
Volume 44, Issue 6, Pages 868-874Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/00397911.2013.837488
Keywords
Catalyst-free; isatin; malononitrile; 4H-pyrans; spirooxindoles
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The synthesis of biologically valuable spirooxindoles and 4H-pyrans is described under catalyst-free conditions through sequential Knoevenagel-Michael-cyclization reactions from isatin or aromatic aldehyde, malononitrile, and 1,3-dicarbonyl compounds. The reaction conditions are very simple, providing excellent yield. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) for the following free supplemental resource(s): Full experimental and spectral details.]
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