ONE-POT, CATALYST-FREE SYNTHESIS OF SPIROOXINDOLE AND 4H-PYRAN DERIVATIVES

The synthesis of biologically valuable spirooxindoles and 4H-pyrans is described under catalyst-free conditions through sequential Knoevenagel-Michael-cyclization reactions from isatin or aromatic aldehyde, malononitrile, and 1,3-dicarbonyl compounds. The reaction conditions are very simple, providing excellent yield. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) for the following free supplemental resource(s): Full experimental and spectral details.]