Journal
SYNTHETIC COMMUNICATIONS
Volume 44, Issue 11, Pages 1658-1663Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/00397911.2013.869603
Keywords
anti-1,3-aminoalcohol; 2-(2-hydroxyalkyl)piperidine alkaloids; Prins-Ritter amidation; ring-closing metathesis (RCM)
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Funding
- CSIR, New Delhi
- IICT-Hyderabad
- UGC, New Delhi
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A stereoselective total synthesis of the 2-(2-hydroxyalkyl) piperidine alkaloids has been accomplished by a Prins-Ritter amidation sequence. Other steps involved in this synthesis are Jacobsen's hydrolytic kinetic resolution (HRK) and ring-closing metathesis (RCM).
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