Journal
SYNTHETIC COMMUNICATIONS
Volume 44, Issue 9, Pages 1240-1244Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/00397911.2013.850092
Keywords
synthesis; epigoitrin; chiral pool; Anticancer activity; antiviral activity
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Funding
- Chinese National Science Foundation [81072514]
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Epigoitrin is the main bioactive constituent of an important traditional Chinese herbal medicine, Radix isatidis. Reported pharmacological effects of epigoitrin include antiviral, anticancer, and antithyroid activities. Extensive biological exploration of epigoitrin was constrained by the limited natural source. This article describes our continued effort toward chemical preparation of epigoitrin from the readily available L-ascorbic acid. Our new developed synthetic route is composed of nine steps, with an overall yield of 17%.
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