SYNTHESIS OF β-ARYL-β-SULFANYL KETONES BY A SEQUENTIAL ONE-POT REACTION USING KF/Al2O3 IN GLYCEROL

The title compounds were synthesized by a sequential one-pot reaction of aryl aldehydes, aryl-methyl ketones, and thiols promoted by KF/Al2O3. This methodology affords a large number of -aryl--sulfanyl ketone derivatives from aliphatic and aromatic thiols in good yields and is also applicable for solid substrates. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) for the following free supplemental resource(s): Full experimental and spectral details.]