Journal
SYNTHETIC COMMUNICATIONS
Volume 43, Issue 12, Pages 1721-1726Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/00397911.2012.666315
Keywords
CTACl catalysis; four-component reaction; pyrano[2; 3-c]pyrazole derivatives; water medium
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Funding
- National Natural Science Foundation of China [21162008]
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An environmentally benign four-component reaction in aqueous medium in the presence of cetyltrimethylammonium chloride (CTACl) has been developed for the synthesis of 6-amino-3-methyl-4-aryl-/1-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile. The method presented is mild, environmentally friendly, inexpensive, and functionality tolerant and gives the products in good to excellent yields.
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