Journal
SYNTHETIC COMMUNICATIONS
Volume 43, Issue 16, Pages 2242-2245Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/00397911.2012.697595
Keywords
Azide; borylation; photoaffinity
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Funding
- Potts Foundation [95440]
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Methyl 3-azidomethyl-5-azido-benzoate (1b) and its corresponding hydroxymethyl reduction product (1a) have been utilized for the synthesis of valuable nonradioactive photoaffinity probes. Previous preparations of (1a) depend upon a nonselective monoactivation of a bis-1,3-hydroxymethylaryl intermediate, leading to the expected statistical range of products/starting material. We report an alternate synthetic approach to these 1,3,5-trisubstituted molecules using recently described C-H activation and boronate refunctionalization methods. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications((R)) to view the free supplemental file.
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