4.3 Article

METAL-FREE, ONE-POT OXIDATIVE CONVERSION OF ALDEHYDES TO PRIMARY THIOAMIDES IN AQUEOUS MEDIA

Journal

SYNTHETIC COMMUNICATIONS
Volume 44, Issue 3, Pages 408-416

Publisher

TAYLOR & FRANCIS INC
DOI: 10.1080/00397911.2013.808350

Keywords

Aldehydes; deoxygenation; green chemistry; nitriles; O; O-diethyl dithiophosphopric acid; thioamides

Funding

  1. Department of Science and Technology (DST), Goverment of India [IFA-11CH-08]
  2. Council of Scientific and Industrial Research, New Delhi

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One-pot tandem reactions of a variety of aldehydes with aqueous ammonia, molecular iodine, and O,O-diethyl dithiophosphoric acid readily afford the corresponding primary thioamides. This is an inexpensive, practical, and metal-free way of accessing various thioamides from aldehydes in aqueous media. The pure products are obtained simply by filtration followed by successive washing with aqueous sodium thiosulfate and water. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) for the following free supplemental resource(s): Full experimental and spectral details.]

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