Journal
SYNTHETIC COMMUNICATIONS
Volume 42, Issue 19, Pages 2854-2865Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/00397911.2011.570891
Keywords
Diversity-orientated synthesis (DOS); E/Z isomers; Grubbs' catalyst; macrocycles; ring-closing metathesis (RCM)
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A convergent, general synthetic route to 17-membered macrocycles was developed to support biological evaluation and structure-activity relationship (SAR) studies during phenotypic screening for immunology targets. A series of amide coupling reactions led to a ring-closing metathesis (RCM) precursor that was cyclized using Grubbs' catalysts. It was found that the reaction formed the macrocyclic products in a 3:1 ratio of E/Z isomers. Moreover, it was shown that a number of similarly substituted RCM precursors undergo cyclization to produce the geometric E/Z isomers in roughly the same 3:1 ratio. The remarkable independence of the E/Z outcome from the substitution pattern of the RCM precursor makes this synthetic approach generally applicable. Separation of the E/Z isomers was achieved by preparative high-performance liquid chromatography and allowed biological profiling of the geometric isomers. Reactive groups in the macrocycle were utilized for late-stage modifications in the fashion of diversity-orientated synthesis (DOS), yielding analogs for SAR studies.
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