Journal
SYNTHETIC COMMUNICATIONS
Volume 41, Issue 19, Pages 2859-2869Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/00397911.2010.515360
Keywords
Amides; amination; 2-aminopyridines; 2-chloropyridines; 2-(N,N-dimethyl)aminopyridines; microwave irradiation
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Funding
- MEC [SAF2006-08764-C02-01]
- Comunidad de Madrid [S/SAL-0275-2006]
- Instituto de Salud Carlos III [RETIC RENEVAS (RD06/0026/1002)]
- AECI [A/07492/07]
- CSCI
- Instituto de Salud Carlos III (Ministerio de Salud y Consumo)
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A simple, quick, and high-yielding microwave-assisted synthesis of 2-(N,N-dimethyl)amine- and 2-aminopyridine derivatives is reported here for the first time in the reaction of 2-chloro substituted pyridines with amide solvents such as dimethylformamide or formamide, without transition-metal catalysts.
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