HIGHLY STEREOSELECTIVE SYNTHESIS OF beta-AMINO KETONES VIA A MANNICH REACTION CATALYZED BY CELLULOSE SULFURIC ACID AS A BIODEGRADABLE, EFFICIENT, AND RECYCLABLE HETEROGENEOUS CATALYST

The efficient use of cellulose sulfuric acid as a heterogeneous catalyst promotes three-component, one-pot Mannich reaction of various ketones, aromatic aldehydes, and aromatic amines in ethanol to make the corresponding beta-amino ketones with high stereoselectivity in favor of the anti-isomer. This protocol has several advantages such as good yield, mild reaction conditions, no environmental hazards, and simple workup procedure.