Journal
SYNTHETIC COMMUNICATIONS
Volume 41, Issue 15, Pages 2200-2208Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/00397911.2010.501471
Keywords
Biginelli reaction; BrOnsted acidic ionic liquid; dihydropyrimidinones; methylimidazolium hydrogen sulfate
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Funding
- Isfahan University of Technology (IUT), Iran
- National Institutes of Health, USA [GM 33138]
- Center of Excellency in Sensor and Green Chemistry Research (IUT)
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[image omitted] An efficient and convenient procedure for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones and thiones by condensation of ethylacetoacetate, aldehydes, and urea or thiourea in the presence of methylimidazolium hydrogensulfate is described. Aromatic and aliphatic aldehydes reacted easily to afford the corresponding 3,4-dihydropyrimidin-2(1H)-ones and thiones under solvent-free conditions. The use of nontoxic and inexpensive materials, straightforward and clean workup, short reaction times, and good yields are the advantages of this method.
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