4.3 Article

One-Pot Multicomponent Condensation Reaction of Aldehydes with Cyclic Ketones

Journal

SYNTHETIC COMMUNICATIONS
Volume 41, Issue 6, Pages 841-850

Publisher

TAYLOR & FRANCIS INC
DOI: 10.1080/00397911003706990

Keywords

Acridine; aldol condensation; aromatic aldehyde; cyclic ketone; microwave irradiation; pyridine

Funding

  1. National Natural Science Foundation of China, China [20672091]

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[image omitted] Under microwave irradiation, the one-pot multicomponent condensation reaction of three molar aromatic aldehydes with two molar cyclic ketones having free ,'-methylene positions such as cyclopentanone or cyclohexanone in the presence of ammonium acetate and acetic acid afforded dicyclocalkenopyridines with two -arylidene groups in good yields. In similar reaction conditions, 1-tetralone, which has only one -methylene position, results in 10-aryl-2,3:5,6-dibenzoacridines.

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