Journal
SYNTHETIC COMMUNICATIONS
Volume 41, Issue 14, Pages 2152-2160Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/00397911.2010.499488
Keywords
1; 4-Dihydropyridines; grinding; Hantzsch reaction; multicomponent reaction; solvent-free
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Funding
- Research Office of Azarbaijan University of Tarbiat Moallem
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[image omitted] An efficient and environmentally friendly synthesis of 6-amino-5-cyano-1,4-dihydropyridine derivatives was developed by the one-pot reaction of ethyl acetoacetate, [(2-aryl)methylene]malononitriles, and ammonium acetate at room temperature with grinding. The key advantages are the short reaction times, good yields, simple workup, and easy purification. The present method does not involve any hazardous solvent.
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