Synthesis of Some 2-Aryl- and 2,3-Diaryl-quinolin-4-carboxylic Acid Derivatives

[image omitted] Eighteen 2-aryl- and 2,3-diaryl-quinolin-4-carboxlic acid derivatives were synthesized. Basically, the synthetic design of these compounds arose from the appropriate disconnections of the target compounds, which revealed pyruvic acid, aromatic amine, and benzaldehyde or phenyl pyruvic acid, aromatic amine, and benzaldehyde as possible logical precursors for 2-aryl- and 2,3-aryl-quinolin-4-carboxylic acids respectively. The purity and identities of the synthesized compounds were elucidated through chromatographic and spectroscopic techniques (ultraviolet, infrared, mass, 1H NMR, and 13C NMR). The prepared derivatives were screened for their antibacterial activity against the standard bacterial organisms B. subtilis, S. aureus, E. coli, and P. vulgaris. 2,3-Diphenyl-6-sulfanilamido-quinolin-4-carboxylic acid showed the highest activity against the four tested organisms.