4.3 Article

Novel Synthetic Route to Fluoxetine

Journal

SYNTHETIC COMMUNICATIONS
Volume 40, Issue 22, Pages 3415-3422

Publisher

TAYLOR & FRANCIS INC
DOI: 10.1080/00397910903422518

Keywords

Curtius rearrangement; fluoxetine; isocyanate

Funding

  1. National Institute on Drug Abuse

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Racemic fluoxetine was synthesized from 3-benzoylpropionic acid in five steps in 54% overall yield.

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