4.3 Article

Efficient One-Pot Synthesis of Benzimidazoles Under Solvent-Free Conditions

Journal

SYNTHETIC COMMUNICATIONS
Volume 40, Issue 19, Pages 2880-2886

Publisher

TAYLOR & FRANCIS INC
DOI: 10.1080/00397910903340629

Keywords

Benzimidazoles; green chemistry; iodobenzene diacetate (IBD); oxidations

Funding

  1. Natural Science Foundation of Zhejiang Province [Y4080126]
  2. Science and Technology Research Program of Zhejiang Province [2008C12084]
  3. Natural Science Foundation of Zhejiang University of Technology [116004029]

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A green, efficient method for the synthesis of various 2-aryl-benzimidazoles in the presence of hypervalent iodine as the oxidant at room temperature under solvent-free conditions is reported. The salient features of this method include mild conditions, short reaction times (3-5min), excellent yields, and simple procedure.

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