MICROWAVE-ASSISTED THREE-COMPONENT REACTION FOR RAPID SYNTHESIS OF SOME 5,6-DIHYDRO-4H-1,3-THIAZINE DERIVATIVES UNDER SOLVENT-FREE CONDITIONS

Microwave irradiation was found to efficiently promote the three-component reaction of aromatic aldehyde, thiourea, and vinylbenzene at the presence of TMSCl. The products of 5,6-dihydro-4H-1,3-thiazines were formed in a very short time with good to excellent yields as well as excellent diastereoselectivity. This newly developed protocol provided a much more facile route of preparing functionalized thiazine compounds. [Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) to view the free supplemental.].