Journal
SYNTHETIC COMMUNICATIONS
Volume 40, Issue 6, Pages 789-798Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/00397910902756197
Keywords
Antibacterial agent; drug-resistant; oxazolidinone; synthesis
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Funding
- National Natural Science Foundation of China [30672537]
- Chengdu Entry Scientific and Technological Development Co., Ltd
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The oxazolidinone class of antimicrobial agents represents a promising advance in the fight against resistant Gram-positive bacterial infections. To improve antibacterial activity and expand the spectrum of activity including Gram-negative bacteria, a series of novel 5-acetylthiomethyl oxazolidinone analogs were designed and synthesized based on the structure-activity relationship studies. The structures of the target compounds and main intermediates were confirmed by 1H NMR, 13C NMR, infrared (IR), mass spectra (MS), and elemental analysis.
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