Journal
SYNTHETIC COMMUNICATIONS
Volume 40, Issue 8, Pages 1209-1215Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/00397910903061076
Keywords
Biginelli; Ce(SO4)2-SiO2; 3; 4-dihydropyrimidinones; solvent-free
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Funding
- Key Discipline of Industrial Catalysis
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A simple and efficient synthesis of 3,4-dihydropyrimidinones or thiones is described, using silica-supported ceric sulfate [Ce(SO4)2-SiO2] as a heterogeneous catalyst from an aldehyde, 1,3-dicarbonyl compound, and urea or thiourea at 110 degrees C under solvent-free conditions. Compared with the classical Biginelli reaction, this new method consistently has better yields, short reaction time, easy separation, and tolerance toward various functional groups.
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