Journal
SYNTHETIC COMMUNICATIONS
Volume 39, Issue 20, Pages 3668-3676Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/00397910902796110
Keywords
Acylthiosemicarbazide; condensation; naphthol; one-pot reaction; solvent-free
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Funding
- Research Council of Arak University
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A new one-pot, multicomponent condensation reaction of aldehydes, 2-naphthol, and 1-acylthiosemicarbazides is described as an efficient method for the synthesis of novel 4-substituted 1-acylthiosemicarbazides in the presence of p-toluenesulfonic acid (p-TSA) as a catalyst under two conditions: organic solvent and solvent-free media. The present procedure offers several advantages, such as good yields, low cost, and very easy workup.
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