Journal
SYNTHETIC COMMUNICATIONS
Volume 39, Issue 5, Pages 880-886Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/00397910802439175
Keywords
Celite; cesium fluoride; dihydropyrimidinones; green chemistry; multicomponent reaction
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Funding
- Commission on Higher Education (CHE-RG)
- Center for Innovation in Chemistry
- Postgraduate Education Program in Chemistry (PERCH-CIC)
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A facile, efficient, and environmentally benign procedure for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones via the cyclocondensation reaction of aromatic aldehyde, ethyl acetoaceate, and urea catalyzed by CsF-Celite was developed. This environmentally friendly method is superior to previous methods with respect to reaction time, yield, and workup.
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