Journal
SYNTHETIC COMMUNICATIONS
Volume 40, Issue 2, Pages 289-294Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/00397910902965970
Keywords
Aromatic aldehyde; isoquinoline; malononitrile; 1-methylpiperidin-4-one; solvent-free conditions
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Funding
- Natural Science Foundation of Jiangsu Education Department [08KJB150017]
- Pei Yu Foundation of Xuzhou Normal University [07PYL06]
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A series of 6-amino-8-aryl-2-methyl-1,2,3,4-tetrahydroisoquinoline-5,7-dicarbonitriles were prepared in good yields under solvent-free conditions by multicomponent reactions of aromatic aldehyde, malononitrile, and 1-methylpiperidin-4-one in the presence of sodium hydroxide (NaOH). The structures of the products were characterized by infrared, 1H NMR spectra, elemental analysis, and high-resolution mass spectrometery (HRMS).
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