Journal
SYNTHETIC COMMUNICATIONS
Volume 39, Issue 22, Pages 4039-4052Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/00397910902883660
Keywords
Asp oligopeptide; bone targeting; convergent synthesis; hydroxyapatite; peptide dendrimer
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Funding
- National Natural Science Foundation of China [20472055]
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The second- and third-generation multiple dendrimers based on naproxen in core and Asp(4-6) oligopeptides in periphery were synthesized in a convergent approach and well characterized by NMR and mass spectral (MS) techniques. These conjugates showed a high affinity to hydroxyapatite in vitro and provided an effective entry for the synthesis of a peptide dendrimer used for bone targeting.
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