Journal
SYNTHETIC COMMUNICATIONS
Volume 38, Issue 21, Pages 3840-3853Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/00397910802238718
Keywords
Boc-deprotection; hexafluoroisopropanol; microwave; trifluoroethanol
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The thermolytic deprotection of N-Boc compounds was accomplished using TFE (2,2,2-trifluoroethanol) or HFIP (hexafluoroisopropanol) as solvents. Even though the cleavage of the t-butylcarbamate (Boc) group can be achieved at solvent reflux temperature, the deprotection process was significantly accelerated under microwave-assisted conditions. The practicality of this methodology was demonstrated on alkyl, aryl, and heteroaromatic N-Boc-amines.
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