Journal
SYNTHETIC COMMUNICATIONS
Volume 38, Issue 7, Pages 1120-1127Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/00397910701863608
Keywords
alpha-acyloxyamides; aromatic aldehydes; Passerini reaction; solvent free
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The influence of the substrate structure and concentration on the yield of the Passerini reaction was studied. A new, solvent-free methodology for a convenient preparation of alpha-acyloxyamides 4 was established and compared to the classical methodology. A higher reaction yield was obtained in shorter time, especially in the case of aromatic aldehydes.
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