ZrOCl2 center dot 8H(2)O-catalyzed one-pot multicomponent synthesis of beta '-acetamido-beta-dicarbonyl compounds with special reference to pref-selective beta '-acetamido-beta-ketoesters

ZrOCl2 center dot 8H(2)O catalyzes the one-pot synthesis of beta'-acetamido-beta-dicarbonyl compounds in high yields from aldehyde, enolizable beta-dicarbonyl compound, acetyl chloride, and acetonitrile in solvent as well as in solvent-free conditions. beta'-Acetamido-beta-ketoesters are formed in moderate to exclusive pref-diastereoselectivity.