Journal
SYNTHESIS-STUTTGART
Volume 51, Issue 2, Pages 516-521Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0037-1609937
Keywords
inorganic base; catalysis; acylation; indole; alkenyl carboxylates
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Funding
- Youth Science and Technology Talent Development Project in Education Department of Guizhou Province [261]
- Innovation Team of Liupanshui Normal University [LPSSYKJTD201601]
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The N -acylation of indoles has been accomplished via inorganic base catalysis. It provided an efficient and simple catalysis system for the preparation of N -acylindoles with alkenyl carboxylates as acylating agents. A broad variety of indoles undergo the smooth N -acylation using Na (2) CO (3) as catalyst in MeCN at 120 degrees C to give the corresponding N -acylindoles in good to excellent yields.
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