Journal
SYNTHESIS-STUTTGART
Volume 46, Issue 8, Pages 1059-1066Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0033-1340815
Keywords
spiro compound; isoquinoline; isatin; indane-1,3-dione; nitrogen ylide; 1,3-cycloaddition
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Funding
- National Natural Science Foundation of China [21172189]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
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A series of novel 2'-aryl-2'-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2',3'-dihydro-10b'H-spiro[indene-2,1'-pyrrolo[2,1-a]isoquinoline]-1,3-diones were efficiently synthesized by three-component reactions of in situ generated N-phenacylisoquinolinium bromides with indane-1,3-dione and isatins in ethanol with triethylamine as the base. A domino reaction mechanism for the formation of the spiro compounds was rationally proposed.
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