Journal
SYNTHESIS-STUTTGART
Volume 46, Issue 14, Pages 1859-1870Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0033-1338637
Keywords
copper; fluorine; alkenes; alkynes; carbohydrates
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Funding
- INSA de Rouen
- Universite de Rouen
- CNRS
- LABEX SynOrg [ANR-11-LABX-0029]
- Region Haute-Normandie (CRUNCh network)
- MESR
- LABEX SynOrg
- China Scholarship Council
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A copper-mediated fluorofunctionalization of alkenes and alkynes has been developed. This method provides ready access to trisubstituted difluoromethylated olefins (from dihydropyrans, glycal derivatives, or terminal alkynes) or to tetrasubstituted olefins (from disubstituted alkynes). The products were obtained in good to high yields with acceptable E/Z selectivities. Finally, a first direct route to difluoromethylated alkynes is reported, albeit with low yields.
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