4.5 Article

Palladium-Catalyzed Asymmetric Allylic Alkylation Reaction of 2-Monosubstituted Indolin-3-ones

Journal

SYNTHESIS-STUTTGART
Volume 47, Issue 1, Pages 134-140

Publisher

GEORG THIEME VERLAG KG
DOI: 10.1055/s-0034-1379043

Keywords

palladium; allylic substitution; asymmetric catalysis; indolines; quaternary carbon

Funding

  1. Major Basic Research Development Program [G 2010CB833300]
  2. National Natural Science Foundation of China [21121062, 21032007, 21302205]
  3. Chinese Academy of Sciences
  4. Technology Commission of Shanghai Municipality
  5. Croucher Foundation of Hong Kong

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An efficient and practical method was developed for the synthesis of 2,2-disubstituted indolin-3-ones by palladium-catalyzed asymmetric allylic alkylation. Enantioselective construction of quaternary carbon centers was also realized in this way.

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