Journal
SYNTHESIS-STUTTGART
Volume 45, Issue 6, Pages 817-829Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0032-1318119
Keywords
gold catalysis; cross-coupling; Sonogashira coupling; gold-palladium combined
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Funding
- DST
- CSIR, Government of India
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A highly efficient gold and palladium combined methodology for the Sonogashira coupling of a wide array of electronically and structurally diverse aryl and heteroaryl halides is described. The orthogonal reactivity of the two metals shows high selectivity and extreme functional group tolerance in Sonogashira coupling. A brief mechanistic study reveals that the gold acetylide intermediate enters into the palladium catalytic cycle at the transmetalation step.
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