Journal
SYNTHESIS-STUTTGART
Volume 46, Issue 1, Pages 49-56Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0033-1340051
Keywords
tetrazoles; tetrahydro-1H--carbolines; MCR; Ugi-azide; Pictet-Spengler
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Funding
- CONACYT [166747 CB-2011-01]
- [CVU 176745]
- [290662_UG]
- [290735_UG]
- [CVU 225689]
- [209242]
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A series of novel 2-tetrazolylmethyl-2,3,4,9-tetrahydro-1H--carbolines were prepared in good to excellent overall yields by an efficient MW-assisted one-pot Ugi-azide/Pictet-Spengler process. This work describes the first synthesis of compounds including both 1,5-disubstituted 1H-tetrazole and 2,3,4,9-tetrahydro-1H--carboline heterocyclic systems.
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