Journal
SYNTHESIS-STUTTGART
Volume 45, Issue 18, Pages 2593-2599Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0033-1338506
Keywords
multicomponent reaction; spirooxindoles; enaminone; hexahydroquinolines; ethylenediamine diacetate
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Funding
- National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology [2012R1A1A4A01009620]
- National Research Foundation of Korea [2012R1A1A4A01009620] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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A simple and efficient one-pot synthesis of biologically interesting spirooxindole derivatives bearing hexahydroquinoline skeleton was accomplished by EDDA-catalyzed, three-component reactions between isatins, malononitrile, and enaminones in good yields. The value of this methodology lies in its inexpensive and nontoxic organocatalyst, mild reaction conditions, and ease of handling.
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