Journal
SYNTHESIS-STUTTGART
Volume 45, Issue 7, Pages 936-942Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0032-1316868
Keywords
N-substituted 2-aminoazoles; iodine; one-pot synthesis; benzoxazole; carbon-nitrogen bond formation
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Funding
- Thailand Research Fund (TRF) [MRG5580039]
- Faculty of Science, Mahidol University
- Center of Excellence for Innovation in Chemistry (PERCH-CIC), Commission on Higher Education, Ministry of Education
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A practical protocol for the one-pot synthesis of N-substituted 2-aminoazole derivatives is described, employing simple azole substrates, nitrogen nucleophiles, lithium tert-butoxide as the base, and iodine to mediate carbon-nitrogen bond formation. This method proceeds at room temperature under an air atmosphere using a normal benchtop set-up, or can be performed conveniently using microwave irradiation.
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