Journal
SYNTHESIS-STUTTGART
Volume 44, Issue 5, Pages 800-804Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0031-1289691
Keywords
amines; azo compounds; drugs; Lewis acids; lanthanides
Categories
Funding
- MIUR
Ask authors/readers for more resources
A simple and efficient method for the synthesis of wide range of 3,3-dimethyl-11-alkyl or aryl 2,3,4,5-tetrahydro-1H-dibenzo[b,e][1,4]diazepin-1-ones, recently reported as hepatitis C virus (HCV) NS5B polymerase inhibitors, is presented. The proposed method consists of one-pot condensation between 1,2-phenylenediamine and 5,5-dimethylcyclohexane-1,3-dione (dimedone) followed by cyclization with various alkyl and aryl acyl chlorides catalyzed by Er(III) triflate. With respect to methods previously reported, the proposed one-pot procedure furnishes appreciably higher yield of product in shorter reaction time.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available