Journal
SYNTHESIS-STUTTGART
Volume 44, Issue 10, Pages 1485-1490Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0031-1290820
Keywords
bimetallic reagents; copper; boron; carbene complex; enantioselective substitution
Categories
Funding
- NSF [CHE-0809261, 1152020]
- Pfizer
- Corning Glass
- FSU
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1152020] Funding Source: National Science Foundation
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We demonstrated the synthesis of chiral annulated six-membered-ring N-heterocyclic carbenes (6-NHC) and their adducts with water and alcohol. We also have shown the donating properties of chiral annulated 6-NHCs is between that of typical 5-NHCs and 6-NHCs. We have shown the synthetic conditions for 6-NHC-copper complex formation. Using the chiral 6-NHC-copper complex, we synthesized unsaturated chiral bimetallic allylic boronate reagents with high enantioselectivity. Finally, we propose a catalytic cycle that justifies observed reactivity and provides a new explanation for the role methanol has in the reaction cycle; our cycle is supported by a primary kinetic isotope effect.
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