Journal
SYNTHESIS-STUTTGART
Volume 44, Issue 4, Pages 619-627Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0031-1289663
Keywords
acylation; arylation; catalysis; coupling; heterocycles; indoles; Lewis acids; palladium
Categories
Funding
- CSIR, New Delhi
Ask authors/readers for more resources
An efficient two-step approach, comprising the Friedel-Crafts reaction of 2-bromobenzoyl chlorides with indoles to give 3-(2-bromobenzoyl) indoles and their palladium-catalyzed intramolecular direct arylation to give indenoindolones, has been developed. 3-(2-Bromobenzoyl) indoles were crucial intermediates; the method was successful with N-unprotected or N-protected indoles. This approach affords a convenient preparation of diverse substituted and functionalized indenoindolones in good to high yields from easily accessible starting materials. Several moieties, which are commonly integrated into bioactive compounds, can be incorporated with ease by this synthesis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available