Journal
SYNTHESIS-STUTTGART
Volume 44, Issue 23, Pages 3678-3682Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0032-1317341
Keywords
2-oxazolines; thioamides; 2-aminoethanol; transamidation; cyclodehydrosulfurisation
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Transamidation of thioamides with 2-aminoethanol, followed by cyclodehydrosulfurisation of the resultant N-(beta-hydroxyethyl)thioamides, has been utilised for the mild and efficient synthesis of 2-oxazolines. The developed protocol was found to be of general applicability.
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