Journal
SYNTHESIS-STUTTGART
Volume 44, Issue 3, Pages 389-392Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0031-1289657
Keywords
catalyst-free; water; Friedlander reaction; ketones; quinolines
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Funding
- National Nature Science Foundation of China [20672035]
- Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
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A straightforward and efficient method for the synthesis of quinolines via Friedlander reaction of 2-aminobenzaldehyde with various ketones or malononitrile in water without using any catalyst at 70 degrees C is reported.
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