4.5 Review

Advances in the Direct Amination of Azole C-H Bonds

Journal

SYNTHESIS-STUTTGART
Volume -, Issue 21, Pages 3408-3417

Publisher

GEORG THIEME VERLAG KG
DOI: 10.1055/s-0030-1260231

Keywords

amides; amines; amination; coupling; heterocycles

Funding

  1. Jiangxi Provincial Department of Education, P.R. of China [GJJ10390]

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The direct amination of azole C-H bonds provides a straightforward, effective access to nitrogen group containing azoles without the prefunctionalization of azoles. This review discussed the rapid advances in the direct amination of azoles; copper-catalyzed/mediated amination, acid-promoted amination, and metal-free amination are discussed.

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