Journal
SYNTHESIS-STUTTGART
Volume -, Issue 20, Pages 3267-3270Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0030-1260191
Keywords
quinolines; multicomponent reactions; one-pot synthesis; nitroarenes; indium; hydrochloric acid
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Funding
- UGC
- CSIR, New Delhi
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Three-component reactions of nitroarenes, aldehydes, and phenylacetylene in the presence of indium in dilute hydrochloric acid produce the corresponding quinoline derivatives under reflux. The conversion in this one-pot synthesis involves the following steps: (i) reduction of the nitroarenes to anilines, (ii) coupling of the anilines, aldehydes, and phenylacetylene, (iii) cyclization of the resulting species, and (iv) dehydrogenation of the cyclic intermediates. Several new quinolines have been prepared.
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