4.5 Article

Synthesis of N-Fmoc-Protected Amino Alkyl Thiocyanates/Selenocyanates and Their Application in the Preparation of 5-Substituted S/Se-Linked Tetrazoles

Journal

SYNTHESIS-STUTTGART
Volume -, Issue 9, Pages 1447-1455

Publisher

GEORG THIEME VERLAG KG
DOI: 10.1055/s-0030-1259972

Keywords

amino acid derivatives; thiocyanates; selenocyanates; [2+3] cycloaddition; S/Se-linked tetrazoles

Funding

  1. University Grants Comission (UGC) [37-79/2009 (SR)]
  2. Department of Science and Technology (DST), New Delhi, India [SR/S1/OC-26/2008]

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A novel class of N-Fmoc-protected amino alkyl thiocyanates/selenocyanates has been prepared by thiocyanation/selenocyanation of the corresponding alkyl iodides. These thiocyanates/selenocyanates undergo a facile [2+3]-cycloaddition reaction with sodium azide to afford novel N-Fmoc amino alkyl S/Se-linked tetrazoles.

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