Journal
SYNTHESIS-STUTTGART
Volume -, Issue 21, Pages 3471-3474Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0030-1260228
Keywords
1,2,3,4-tetrasubstituted pyrroles; four-component coupling reaction; iodine; metal-free synthesis
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Funding
- CSIR, New Delhi
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The four-component coupling reaction of aldehydes, amines, dialkyl acetylenedicarboxylates, and nitromethane in the presence of molecular iodine as a catalyst furnished the corresponding 1,2,3,4-tetrasubstituted pyrroles under reflux. The products are formed in high yields (65-88%) within 8 hours. The method is simple, efficient, cost-effective, and metal-free.
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