Journal
SYNTHESIS-STUTTGART
Volume -, Issue 23, Pages 3827-3838Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0030-1260260
Keywords
alkyl sulfoximines; dihydro benzothiazines; desymmetrization; cyclizations; copper
Categories
Funding
- Alexander von Humboldt foundation
- Syngenta
- Fonds der Chemischen Industrie
Ask authors/readers for more resources
Enantiomerically enriched forms of a sulfoximine-based myristic acid analogue are prepared using either an asymmetric desymmetrization with a chiral base, or an enantioselective oxidation procedure as key steps. Additionally, a variety of 2-oxa-2-alkyl 3,4-dihydro 2,1-benzothiazines are synthesized via intramolecular metal-catalyzed N-arylation of appropriately functionalized sulfoximines with tethered 2-bromoaryl substituents. In turn, the sulfoximines are prepared by lithiation-alkylation sequences including enantioselective deprotonation steps or the use of an optically active sulfoxide. Using this methodology, the range of accessible 3,4-dihydro 2,1-benzothiazine derivatives is expanded.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available