Copper(II) Triflate Promoted One-Pot Synthesis of Coumarin-, Quinolone-, and Naphthalene-Annulated 2-Aminothiazoles under Ligand-Free Conditions

An efficient synthesis of new 2-aminothiazole-annulated compounds is described via copper(II) triflate promoted sequential condensation, arylation, and heterocyclization reactions in one step. The reaction is compatible with a variety of substrates providing efficient access to many biologically important skeletons in good yields.